The 'large molecules' to be discussed in the course include oligonucleotides, antibodies, antibody fragments and proteins. The following topics will be discussed:
LC-MS/MS
Immunoassays
Immunogenicity
ADME and PK/PD

This course is intended for new DMPK scientists, or those from other scientific disciplines, who would like a broad introduction to DMPK science. This course covers a range of topics highlighting the pivotal role played by DMPK throughout the drug discovery and development process. Specific consideration is given to topics as diverse as, in vitro metabolism, pharmacokinetics, quantitative analytical techniques, qualitative detection methodology and isotopic techniques. In addition, consideration is also given to topics which have taken on a greater prevalence in recent years, for example, modelling & simulation techniques and an introduction to the DMPK aspects of large molecules.

Increasingly, DMPK departments are involved in the design and analysis of in vivo pharmacology (PKPD) experiments. This 2 day course aims to cover the basic concepts of PKPD that will allow scientists to start practising PKPD interpretation. The course is for DMPK scientists, and their biology and pharmacology colleagues, who want to learn more about the PKPD and its uses for drug discovery and development.

This 3 day course should appeal to those scientists just starting their careers in this area or those from other scientific disciplines who want to learn more of these approaches and how to apply them to the drug discovery and development process. Topics to be covered include the enzymology of drug metabolism, enzyme kinetics, induction of ADME targets, drug transport processes, the use of hepatocytes, slices and subcellular fractions and the influence of molecular technologies on our discipline.

The 'large molecules' to be discussed in the course include oligonucleotides, antibodies, antibody fragments and proteins. The following topics will be discussed:
LC-MS/MS
Immunoassays
Immunogenicity
ADME and PK/PD

The objectives for the DMDG course on Pharmacokinetics in Drug Discovery are to develop an understanding and appreciation of the importance and contribution of drug metabolism and pharmacokinetics to drug design by first intent. The course highlights the importance of physicochemical properties in drug design and covers the fundamental aspects of pharmacokinetics and pharmacodynamics, safety study design and toxicokinetics, the importance of ADME and the relevance of metabolite pharmacokinetics.

The agenda includes a series of interactive tutorials interspersed between more formal lectures, designed to give delegates a deeper understanding of bioanalytical tools employed within the DMPK environment. The tutorials aim to reinforce lecture material, but in a more practical form. Topics include:
Physico-chemical Properties of Drugs
Fundamental Aspects of Mass Spectrometry (MS)

This course has been designed to give delegates a broad understanding of whole body autoradiography, from experimental design through to interpretation of results, including regulatory requirements, human dosimetry calculations, methodology and instrumentation. Tissue distribution using MSI will also be discussed. The course is a two day, lecture-based programme, aimed at providing a solid background in autoradiography techniques to study monitors/managers/directors and technicians wishing to improve their understanding of the theoretical background. There is also the option to add a practical third day (at additional cost).

One-day single topic meetings