| Monday
27 November |
19.00-
21.00 |
|
Welcome reception
including poster viewing at the Hope Street Exchange |
|
|
|
|
|
Tuesday 28 November |
|
08.30 |
|
Welcome |
|
08.45 |
|
Introductory lecture: A
history and a peer into the future of dermal metabolism
C. Roper, Charles River, UK |
|
|
|
1. Risk Assessment
Chairs: Simon Wilkinson & Clive Roper |
|
09.30 |
|
Skin metabolism "why and how"
- aspects to be considered during development of dermal and
transdermal therapeutics
C. Günther, Bayer, Germany |
|
09.45 |
|
Questions
|
|
09.50 |
|
Risk assessment following
fate of metabolite with AOPs
J. Pickles, Unilever, UK |
|
10.05 |
|
Questions
|
|
10.10 |
|
Contribution of dermal
metabolism to local toxicities
S. Wilkinson, University of Newcastle, UK |
|
10.25 |
|
Questions
|
|
10.30 |
|
Xenobiotic metabolizing enzyme activities in 3D models
and their importance in dermal toxicity tests
N. Hewitt, Cosmetics, Europe, Belgium |
|
10.45 |
|
Questions
|
10.50-
11.10 |
|
Coffee break
|
|
|
|
2. Impact of skin
metabolism on skin pharmacokinetics
Chairs: Joan Eilstein & Clemens Günther |
|
11.10 |
|
Extrahepatic metabolism at
the body's internal-external interfaces
U. Gundert-Remy, Charité Berlin, Germany |
|
11.25 |
|
Questions
|
|
11.30 |
|
The pharmacokinetics (ADME)
of delivering active molecules to the skin
R. Guy, University of Bath, UK |
|
11.45 |
|
Questions
|
|
11.50 |
|
Using skin metabolism to
assess bioavailability
A.H. Eriksson, LEO Pharma A/S, Denmark |
|
12.05 |
|
Questions
|
|
12.10 |
|
Challenges and successes of
predicting pharmacokinetics following topical dosing
C.E. Wilson, Nestlé Skin Health, France |
|
12.25 |
|
Questions
|
12.30 -
14.00 |
|
Lunch
|
|
|
|
3. Drug transporters in the skin
Chairs: Hanan Osman-Ponchet & Sylvain
Ghilini |
|
14.00 |
|
Drug transporters in the skin
and their importance in dermal absorption
H. Osman-Ponchet, Galderma, France |
|
14.15 |
|
Questions
|
|
14.20 |
|
Skin metabolism and active transport in transdermal drug delivery
Y.H. Dancik, A*STAR, Singapore |
|
14.35 |
|
Questions
|
|
14.40 |
|
Transporters Characterization
in human skin compared with 3D models
J. Eilstein, L'Oréal, France |
|
14.55 |
|
Questions
|
15.00-
15.30 |
|
Coffee break
|
|
|
|
4. Illustration of studies in the skin metabolism field
Chairs: Kalliopi Dodou & Simon Wilkinson |
|
15.30 |
|
Harmful synergy between UV
and pollutants: redox metabolism study of skin cells
J. Soeur, L'Oréal, France |
|
15.45 |
|
Questions
|
|
15.50 |
|
Variation of xenobiotic
metabolism in the skin and skin models of various animal species and
man and consequences for genotoxicity
F. Oesch, Oesch-Tox, Germany |
|
16.05 |
|
Questions
|
|
16.10 |
|
Passive transdermal delivery of low-dose naltrexone;
detection of naltrexone and its active metabolite, 6β-naltrexol, using a novel LC Q-ToF MS assay
K. Dodou, University of Sunderland, UK / Kevin Carr, Analutos Ltd |
|
16.25 |
|
Questions
|
|
16.30 |
|
Skin Metabolism of Aromatic
Amine Hair Dyes as Xenobiotics
C. Goebel, Coty, Germany |
|
16.45 |
|
Questions
|
|
16.50 |
|
Poster blitz
Chairs: Kalliopi Dodou & Richard Guy |
|
17.20 |
|
Poster session & Cocktails
|
|
18.30 |
|
Bus transport to the National
Glass Centre
|
|
19.00 |
|
Dinner at the National Glass
Centre Brasserie
|
|
|
|
|
|
Wednesday 29 November |
|
|
|
5. Which models can be
used to study skin metabolism
Chairs: Carine Jacques-Jamin & Juliette
Pickles |
|
08.45 |
|
An iPSC generated model of skin – 5 cells are better than 2
L. Armstrong, Newcells Biotech Ltd., UK |
|
09.00 |
|
Questions
|
|
09.05 |
|
New skin-on-chip platform for high-precision skin permeation testing
Y.H. Dancik, A*STAR, Singapore |
|
09.20 |
|
Questions
|
|
09.25 |
|
Xenobiotic metabolism in
human and pig skin models
C. Jacques-Jamin, Pierre-Fabre, France |
|
09.40 |
|
Questions
|
|
09.45 |
|
Student presentations:
Studies on the skin metabolism of parabens
M. Golam, University of Sunderland, UK
Sunscreens and the effects of electromagnetic radiation exposure on human skin
E. Rashdan, Newcastle University, UK |
10.15-
10.40 |
|
Coffee break
|
|
|
|
6. Novel analytical
techniques for imaging drugs and metabolites in the skin
Chairs: André Huss Eriksson & Kalliopi
Dodou |
|
10.40 |
|
Advantages and limits of
analytical methods to study skin metabolism
S. Gregoire, L'Oréal, France |
|
10.55 |
|
Questions
|
|
11.00 |
|
Mass spectrometry imaging by
MALDI and DESI for studies of delivery and metabolism of drugs in
skin
Christian Janfelt, University of
Copenhagen, Denmark |
|
11.15 |
|
Questions
|
|
11.20 |
|
Illustration of advantages of
imaging approaches in studying skin metabolism compared to
traditional analytical methods
S. Ghilini, Nestlé Skin Health, France |
|
11.35 |
|
Questions
|
|
11.40 |
|
Metabolism of xenobiotics in
human reconstituted epidermis: In situ investigation by HRMAS NMR
J.-P. Lepoittevin, University of
Strasbourg, France |
|
11.55 |
|
Questions
|
|
12.00 |
|
Closing session and student
poster prize
|
12.30 -
14.00 |
|
Lunch and depart
|
